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KMID : 0363319990200010083
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Journal of Korean Oriental Internal Medicine
1999 Volume.20 No. 1 p.83 ~ p.98
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Effects of Samul-Tang Extract on Vascular Endothelial Cells from Hydrogen Peroxide-induced Injury
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Nam Chang-Gyu
Kim Young-Kyun
Moon Byung-Soon
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Abstract
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This study is designed to investigate the effects of Samul-Tang extract on the response of lactic dehydrogenase(LDH) release, cellular activity, lipid peroxidation, DNA synthesis and the changes of total protein of bovine pulmonary artery endothelial cells(PAEC) from hydrogen peroxide-induced injury.
The results are as follows :
1. Samul-Tang significantly decreased -induced release of LDH from injured bovine PAEC.
2. Samul-Tang significantly repressed -induced cellular activity from injured bovine PAEC.
3. Samul-Tang significantly repressed -induced lipid peroxidation from injured bovine PAEC.
4. Samul-Tang significantly stimulated DNA synthesis in bovine PAEC.
5. Samul-Tang significantly repressed -induced changes of total protein volume from injured bovine PAEC.
Above results suggest that Samul-Tang can protect bovine PAEC from -induced injury. These results can be effectively applied to the prevention and cure of cardiovascular and cerebrovascular diseases.
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KEYWORD
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Samul-Tang extract(SMT), vascular endothelial cell, pulmonary artery endothelial cells(PAEC), hydrogen peroxide
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